Shiki awakes from her coma and starts to live a new life. Meanwhile, a series of murders are occurring after four years of silence. “Who is the murderer?” The incidents remind her of a murderous impulse hidden inside her soul and “SHIKI,” her lost alternate persona. While Shiki searches for a suspect, Mikiya also starts an investigation of his own to prove Shiki is innocent. As he follows a lead of a drug dealer, Mikiya comes across Rio Shirazumi, who was a senior at his high school. Mikiya finds out that Rio is the one who sells the drug called “blood chip” and tries to convince him to stop, but he is instead harmed by Rio.

[Source: Aniplex of America]