Chris Redfield of the anti-bioterrorism organization BSAA infiltrated a mansion after receiving a tip that it was in fact the home base for an arms dealer ring. Although he found himself squared off with world-famous wanted criminal Glenn Arias during his investigation, he ended up having to flee from him after witnessing something unbelievable.
On the other hand, Rebecca Chambers–a former member of Raccoon City's special police force S.T.A.R.S. and current college professor–was involved in the investigation of a baffling incident in which the deceased come back to life and went berserk. Thanks to her efforts during the investigation, she was able to discover that the incidents were being caused by a new kind of virus and develop a medicine to cure it. Soon after this, however, the research lab was attacked by some unknown figure and Rebecca was in mortal danger. Luckily, she managed to survive thanks to Chris and the others who had rushed to her rescue.
After these events, Chris and Rebecca headed to meet up with Leon S. Kennedy, a member of the DSO, an organization of agents under direct control from the U.S. President… Leon was the most knowledgeable individual when it came to the incidents involving this new virus. After being apart, Chris and Leon finally reunite. Knowing that Arias' true goal is bioterrorism, Chris, Leon, and Rebecca go to New York to find him, stop his plans, and save humanity.
(Source: Anime Now)